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KMID : 0363620090300030061
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 3 p.61 ~ p.69
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Anti-metastatic and Immunomodulating Activity of Water-Soluble Components from Five Mushroom Extracts
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Yoo Hwa-Seung
Han Sung-Soo
Kim Jung-Sun
Cho Chong-Kwan
Lee Yeon-Weol
Park Sang-Yong
Lee Soo-Jin
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Abstract
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Objectives : This experiment was conducted to evaluate the inhibitory effects against lung metastasis and promotion of splenocytes by water-soluble components from five mushrooms extracts (WEFM): Garnoderma frondosa, Corious versicolor, Codyceps militaris, Hericium erinaceus and Lentinula edodes.
Methods : Colon 26-L5 carcinoma cells were injected through the tail vein to induce lung metastatic cancer. Changes in weight of lung were observed and cytokine level was analyzed to evaluate immunological changes.
Results : Oral administration of WEFM resulted in a significant inhibition of lung metastasis after intravenous
injection of colon 26-L5 cells in a dose-dependent manner. There was also a significant increase in T cell and B
cell mitogenic stimuli and production of IFN-g by splenocytes stimulated with Con A compared to untreated controls.
Conclusion : WEFM may have anti-tumor activities via Th1-type dominant immune responses.
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KEYWORD
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colon 26-L5 cell, lung metastasis, IFN-γ, Th1 cytokine
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